Role of insulin resistance and insulin action in polycystic ovary syndrome: a concept review

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine-metabolic illness that has alarmingly high rates of infertility and other significant effects on the health women. This review study highlighted Insulin appears to damage every part hypothalamus-hypophysis-ovary axis, insulin resistance in ovarian tissue leads impaired metabolic signalling but intact mitogenic steroidogenic activity, favouring hyperandrogenemia, which thought be primary cause clinical symptoms PCOS. also enumerates briefly summarize research methods related PCOS, including molecular mechanism action anabolic processes stimulate cell growth differentiation; increase protein fat storage; binding between α, β dimers receptors surface results alteration gene expression, metabolism growth.